I do recommend getting familiar with the walkthrough (I haven't used any mods on this game in more than a few updates) if you have particular paths you want to explore. Once you do, it's easy to find where you are, if you have questions, and CTRL past bits you know well.
Though I recently deleted all my old saves (mostly because they allowed the Holly Trinity and slutty Holly to coexist), so I came back to it with a few different playthroughs in mind, to set up for the future. The walkthrough is a slightly odd style, but it's one used by more than a handful of games, so learning to read it can be a useful skill. Like reading a map. Oh, that reminds me, I need to check out the newest update of KG at some point.